35 reviews
Ergo+ Ergothioneine Supplement
Longevity & Skin†
Size
60 Capsules
Quantity
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Ergo+ delivers L-ergothioneine, a rare antioxidant amino acid found in mushrooms and absorbed by a unique transporter in your body. Supplementing may support healthy aging, cognitive clarity, and resilience to oxidative stress.† Sourced from golden oyster mushrooms and fermentation, Ergo+ offers pure, effective support for long-term wellness.
Whether you're looking to stay sharp as you age or give your cells extra support against environmental stresses, our Ergo+ capsules offer a simple, effective way to nourish your body at the cellular level.
Our formula delivers a pure, concentrated source of L-ergothioneine, an amino acid antioxidant your body can’t make, but is built to absorb.
Real Mushrooms Ergo+ contains no mycelium, grain, or unnecessary fillers, just clean, verified ingredients designed to support long-term wellness.
Research-backed benefits of L-ergothioneine:†
- Supports healthy cognitive function and mental clarity
- Promotes antioxidant defenses against oxidative stress
- Helps maintain cellular health as you age
- Supports overall well-being and resilience
- Backed by emerging human research on healthy aging and neuroprotection
Take 1 capsule daily with or without food, or as recommended by your healthcare professional.
Many customers find it easiest to incorporate Ergo+ into their morning wellness routine, paired with other Real Mushrooms best-sellers like Lion’s Mane or Reishi.
Real Mushrooms products are always:
- Rated the #1 Mushroom brand by ConsumerLab
- Made from USDA Certified Organic Mushrooms
- Verified for active compounds, safety, & purity through third-party testing
- Purity-IQ verified for authenticity using nuclear magnetic resonance
- Free of grains, starches, and fillers
- Sourced from mushroom (fruiting bodies) only—never mycelium fermented grain
- Produced in a Good Manufacturing Practices (GMP)-compliant facility
This is our Real Mushrooms Guarantee: no shortcuts, no gimmicks—just real mushrooms.
100 Days
100 Days
Money-Back Guarantee
94,000+
94,000+
5 star reviews
50+ Years
50+ Years
Growing experience
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Real Ingredients
An Amino Acid for Healthy Aging & Healthy Cognition
L-ergothioneine is a rare antioxidant amino acid found naturally in mushrooms, our richest source. Though our bodies can’t produce it, we’ve evolved a specific transporter to absorb and retain it, underlining its importance in human health. Research shows ergothioneine levels decline with age, and maintaining them may support cognitive health, cellular resilience, and healthy aging.
Ergo+ delivers a clean, natural source of L-ergothioneine from golden oyster mushrooms to help promote mental clarity and long-term well-being.
Real Mushrooms, Not Filler
Most mushroom supplements fail because they’re made without mushrooms: they use mycelium fermented grain. Those products have few beneficial fungal compounds—they’re mostly starch.
We use 100% hot water-extracted mushrooms (fruiting body) to unlock the true full spectrum of beneficial compounds.
Highest-Quality, Organic Ingredients
We partner with experienced mushroom growers using Di Dao 地道 (spiritual homeland) cultivation practices to harvest mushrooms in their geo-authentic environments. Our Ergo+ contain only the real mushroom, grown, extracted, and tested with integrity.
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5-Time Winner
Best Mushroom Supplement Brand: ConsumerLab.com Survey
Trusted by wellness seekers and professionals alike, our mushroom supplements have earned the rating of Best Mushroom Supplement Products five years in a row by consumers in ConsumerLab.com Annual Supplement Survey.
†Ratings based on results of the 2025 ConsumerLab.com Survey of Supplement Users. More information.
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Real People. Real Results.†
★★★★★
“I have a condition that causes constant fatigue. After taking the Ergo+ for a week or so, I started to feel a difference. I have more stamina through the day, and my mind feels clearer.”†
– Verified Customer
★★★★★
“I have a condition that causes constant fatigue. After taking the Ergo+ for a week or so, I started to feel a difference. I have more stamina through the day, and my mind feels clearer.”†
– Verified Customer
★★★★★
“It added a sharpness and speed to my thinking and processing... At almost 70 it is a joy to have words come to mind easily, and if I've misplaced my keys the last place I put them down comes readily to mind. I love my mushrooms!”†
– Verified Customer
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Real Science
Real Mushrooms is built on 50+ years of mycological and mushroom growing expertise. Our founder’s roots trace back to the beginning of the functional mushroom category in North America. Today we continue to lead the industry in science-backed and effective mushroom supplements.
Every batch of 5-Defenders is lab-verified for beta-glucan content and free of unwanted fillers like starch or alpha-glucans from grain. This scientific transparency ensures that what’s on the label is exactly what’s in the bottle.
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Real Quality
Why Beta-Glucans Matter
Beta-glucans are the primary active compounds in Ergo+ mushrooms that support immune function.* Most mushroom products don’t list beta-glucan content, but we do.
Beta-Glucans indicate an authentic mushroom product versus myceliated grain products that contain high levels of starch (Alpha-Glucans) instead.
Real Mushrooms offer potency you can trust, in every capsule.
We use only 100% mushroom (fruiting body)—no grain, no mycelium, no fillers.
This product has received the Purity-IQ™ Authenticity Certification Program - a cutting-edge nuclear magnetic resonance technique that confirms we use the correct mushroom species and nothing else.
View our certification on Purity-IQ
Certified organic. Verified species identity. No shortcuts. Just clean, potent mushrooms—exactly as nature intended.
We partner with experienced mushroom growers using Di Dao 地道(spiritual homeland) cultivation practices to harvest mushrooms in their geo-authentic environments. Our mushroom Ergo+ extract contains only the real mushroom—grown, extracted, and tested with integrity.
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Real Mushrooms vs. Other Brands
Not all mushroom supplements are created equal. Real Mushrooms has set the standard for the most effective mushroom products because we have never compromised on quality. Here’s how Real Mushroom supplements compare with the other leading brands on the market.
Real Mushrooms
100% organic mushrooms
Guaranteed >30% beta-glucans
Hot water extracted or dual extracted
No starch · no fillers
Full disclosure of ingredients, sourcing, testing and extraction
Cost-effective for active compound concentration in every serving
50+ years mushroom cultivation expertise
Other Brands
Mycelium fermented grain (starch + fillers)
Typically low, often undisclosed
Improperly extracted or simply dried and ground
Commonly contains rice, oats or sorghum starch and/or maltodextrin
Vague or misleading marketing and unclear labeling
Very expensive for amount of active compounds actually present
Mislead customers with ambiguous labeling and filler-heavy products
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Take the guesswork out of your mushroom supplement.
Start enjoying real results now.
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100% organic mushroom extracts
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Verified beta-glucans
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No grain fillers
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50 years of experience
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Wellness backed by 40,000+ customers
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philippe y. I started taking mushroom supplements (Reishi, Cordyceps, Tremella, Ergo+, and Lion's Mane) in January 2026. I am an active 55-year-old man. I complement this regimen with a healthy lifestyle (exercise, diet). I feel fitter, more focused, and more present in my daily life. I love my morning and evening routine, taking my supplements and reminding myself each time how important it is to take care of myself.
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J. I have noticed the difference when I’m taking the Ergo consistently. It’s been about six months and each month I see increases in memory ,cognitive ease, and fluidity of verbal expression. Love real mushrooms for their cleanliness and devotion to purity.
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Sarah K. A few months ago, I went for my yearly physical. My blood pressure was higher than last time. I had a feeling it would be because sometimes it pounded when I walked up stairs, or mowed the lawn, or exercised.
I asked the doctor what could be done about it, and she said a lot of times it’s hereditary (I have a history of heart problems in my family). She said I could take a water pill, which I declined at that moment.
As soon as I got home, I started looking up which mushrooms help with heart health. I already take Cordyceps, Lions mane, (at the time Reshi). I found out that both Ergo and Chaga help with heart health. I ordered them, and started taking them, and I kid you not, within less than a week, I saw a HUGE difference. I do have to say, mushroom supplements do affect me pretty quickly.
My heart stopped pounding during more active times. I drank a whole Mexican coke without my heart racing.
Since I’d started taking both Ergo and Chaga, I reached out to the Realmushrooms FB group to ask them if it was one or the other or both. The response I got back is that it’s likely the Ergo since other people have had similar experiences.
I continue to take both of them along with Cordyceps and Lionsmane.
Months later, and my heart is still doing well! I can’t wait to see what my test results show for my next physical 🤩
K
Katy Always great products!
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Beverly I'm still new to this product, but so far I'm impressed.
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Frequently Asked Questions
All our mushroom extracts are from the leading supplier of organic mushroom extracts: Nammex. They have over 40 years of mushroom growing experience and were one of the first companies to bring organic functional mushroom extracts to North America.
Their ingredients go through rigorous quality control and are tested twice for heavy metals, agricultural chemicals and microbial contamination to ensure they meet all standards for dietary supplements of this nature. All of their extracts are made from certified organic mushrooms (fruiting bodies), organically grown or wildcrafted from deep within mountain regions of China.
Mushrooms used for dietary supplements are seldom grown in North America since they are too expensive. China is the leading supplier of mushrooms worldwide and supplies over 90% of the world’s mushrooms.
It has a rich history of mushroom use as both food and medicine and is the birthplace of mushroom cultivation, with shiitake being farmed in the early 1200s. China is one of the only places in the world where you can get 100% organic mushroom (fruiting body) extracts that can be sold at an affordable price.
The products are identical. The only difference is how you want to consume them.
2 capsules is equivalent to roughly a 1/2 tsp of the mushroom powders.
In terms of potency and efficacy, both the capsules and powders are equally effective at delivering.
The capsules are great for travel, whereas the powder can be added to recipes or mixed in coffee, tea or bone broth.
It is extremely important to distinguish the difference between mushrooms and mycelium.
Mushrooms are the "fruit" and reproductive stage of these organisms, while the mycelium is the root system or "body" of the fungus.
Mushrooms contain much higher levels of active compounds like beta-glucans, and there is a large body of research on them. They have also been consumed for thousands of years as food, and many health benefits have been shown from just mushroom consumption.
Mycelium is commonly grown on a grain substrate, and this grain cannot be separated from the mycelium, so much of the final product is actually grain with no mushrooms present. This shows up in high amounts of starch and low amounts of active compounds like beta-glucans.
For these reasons, Real Mushrooms® only utilizes mushrooms in all of its products, with verified levels of important active compounds like beta-glucans, and is always guarded against starchy fillers like grain.
Ergothioneine is a sulfur-based amino acid. Amino acids are important compounds that help the body build proteins. Ergothioneine was discovered in 1909 by Charles Tanret, a French pharmacist and chemist.
This compound holds powerful antioxidant potential, helping to protect cells from oxidative damage. Certain mushrooms, including some of our products, are known to contain high levels of ergothioneine naturally.
Tanret was examining the ergot fungus, which had recently been responsible for destroying crops, and he discovered the compound by using a purification process. The amino acid name ergothioneine originates from this fungus. While the ergot fungus may damage crops, the amino acid it contains helps essential functions in the human body.
Ergo+ provides a natural source of L-ergothioneine, an amino acid studied for its role in supporting cognitive health and oxidative stress balance.* These benefits make it a standout among certain types of mushroom products on the market today for supporting healthy aging.
Natural ingredients don’t always flow smoothly through processing equipment and capsule manufacturers need to utilize other ingredients in order to fill capsules. It is common practise for encapsulation facilities to require the use of other ingredients.
We have worked closely with our encapsulation partners to make sure that only what is added is absolutely necessary to create the capsules.
Beta-glucans are naturally occurring polysaccharides found in mushrooms and are among the most studied compounds for their functional properties*. For this reason, we specifically measure beta-glucan levels on our products.
We do not believe in using polysaccharides as a measure of quality as they can be easily doctored using starch-like substances like grains.
Whether you’re training hard or just looking for more natural energy throughout your day, Cordyceps may help you feel more resilient, active, and ready to perform.
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