931 reviews
5 Defenders® Organic Mushroom Blend Capsules
Immunity†
Size
90 Capsules
Quantity
100% Satisfaction • Fast Free Shipping $75+ • Secure Checkout
Think of 5 Defenders® as your mushroom “multivitamin.”
Whether you're looking for daily wellness support or to maintain long-term health, this pure, organic blend of five functional mushrooms offers a natural and effective solution.
We have crafted a synergistic, optimal immune-supporting mushroom complex based on decades of research and traditional use. Each 5 Defenders® mushroom contributes its own distinct set of bioactive compounds, like beta-glucans, triterpenes, and antioxidants that target different aspects of immune and overall wellness support.
5 Denfenders® creates a broad-spectrum foundation for wellness, supporting not just the immune system, but the conditions that allow it to function optimally.
- Reishi promotes calm and supports a healthy stress response
- Shiitake and Maitake offer immune-modulating compounds and support metabolic function.
- Turkey Tail delivers powerful polysaccharides like PSK and PSP, which may support the activation of important immune pathways.
- Chaga brings potent antioxidant activity to support cellular health.
Take 2 capsules daily with or without food, or as recommended by your healthcare professional.
Many customers find it easiest to incorporate 5 Denfenders® into their morning wellness routine, paired with other Real Mushrooms best-sellers like Lion’s Mane or Cordyceps.
Real Mushrooms products are always:
- Rated the #1 Mushroom brand by ConsumerLab
- Made from USDA Certified Organic Mushrooms
- Verified for active compounds, safety, & purity through third-party testing
- Purity-IQ verified for authenticity using nuclear magnetic resonance
- Free of grains, starches, and fillers
- Sourced from mushroom (fruiting bodies) only—never mycelium fermented grain
- Produced in a Good Manufacturing Practices (GMP)-compliant facility
This is our Real Mushrooms Guarantee: no shortcuts, no gimmicks—just real mushrooms.
Real Ingredients
Balanced Immune Response†
This mushroom complex is a blend of five extract powders: Reishi, Shiitake, Maitake, Turkey Tail mushrooms and Chaga. They are renowned for their naturally high levels of beta-glucans, polysaccharides that can help balance your body's natural immune response.† Our extract is optimized to contain more than 20% beta-glucans, ensuring consistent, effective support in every serving.
Real Mushrooms, Not Filler
Most mushroom supplements fail because they’re made without mushrooms: they use mycelium fermented grain. Those products have few beneficial fungal compounds—they’re mostly starch.
We use 100% hot water-extracted mushrooms (fruiting body) to unlock the true full spectrum of beneficial compounds.
Highest-Quality, Organic Ingredients
We partner with experienced mushroom growers using Di Dao 地道 (spiritual homeland) cultivation practices to harvest mushrooms in their geo-authentic environments. Our 5 Defenders® contain only the real mushroom, grown, extracted, and tested with integrity.
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4-Time Winner
Best Mushroom Supplement Brand: ConsumerLab.com Survey
Trusted by wellness seekers and professionals alike, our mushroom supplements have earned the rating of Best Mushroom Supplement Products four years in a row by consumers in ConsumerLab.com Annual Supplement Survey.
†Ratings based on results of the 2025 ConsumerLab.com Survey of Supplement Users. More information.
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Real People. Real Results.†
★★★★★
“I have been taking it for nearly a year and haven’t even had a common cold!”†
– Verified Customer (C. Sid)
★★★★★
“Incorporating the “5 Defenders”, Lion's Mane, and Reishi Real Mushrooms capsules into my daily regimen was such a wise decision. I feel sharper mentally, calm yet focused, and I’m experiencing expedited healing.”†
– Verified Customer
★★★★★
“I believe it is helping to repair my gut biome. This is something I’ve been working on for a while. Your mushrooms are a better quality than what I was using before. My energy has improved and my sleep quality has also improved.”†
– Verified Customer (Charles T.)
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Real Science
Real Mushrooms is built on 50+ years of mycological and mushroom growing expertise. Our founder’s roots trace back to the beginning of the functional mushroom category in North America. Today we continue to lead the industry in science-backed and effective mushroom supplements.
Every batch of 5-Defenders is lab-verified for beta-glucan content and free of unwanted fillers like starch or alpha-glucans from grain. This scientific transparency ensures that what’s on the label is exactly what’s in the bottle.
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Real Quality
Why Beta-Glucans Matter
Beta-glucans are the primary active compounds in 5-Defenders mushrooms that support immune function.* Most mushroom products don’t list beta-glucan content, but we do.
Beta-Glucans indicate an authentic mushroom product versus myceliated grain products that contain high levels of starch (Alpha-Glucans) instead.
Real Mushrooms offer potency you can trust, in every capsule.
We use only 100% mushroom (fruiting body)—no grain, no mycelium, no fillers.
This product has received the Purity-IQ™ Authenticity Certification Program - a cutting-edge nuclear magnetic resonance technique that confirms we use the correct mushroom species and nothing else.
View our certification on Purity-IQ
Certified organic. Verified species identity. No shortcuts. Just clean, potent mushrooms—exactly as nature intended.
We partner with experienced mushroom growers using Di Dao 地道(spiritual homeland) cultivation practices to harvest mushrooms in their geo-authentic environments. Our mushroom 5-Defenders extract contains only the real mushroom—grown, extracted, and tested with integrity.
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Real Mushrooms vs. Other Brands
Not all mushroom supplements are created equal. Real Mushrooms has set the standard for the most effective mushroom products because we have never compromised on quality. Here’s how Real Mushroom supplements compare with the other leading brands on the market.
| Real Mushrooms | Other Brands | |
|---|---|---|
| Mushroom Source | 100% organic mushrooms (fruiting bodies) | Mycelium fermented grain (starch) and fillers |
| Beta-Glucan Content | Guaranteed beta-glucans — every batch third party tested for identity, purity and potency | Typically low beta-glucans and not disclosed — may list total polysaccharides instead which includes any starches |
| Extraction Method | Hot water extracted or dual extracted for potency & optimal absorption | Improperly extracted or simply dried and ground |
| Filler-Free Guarantee | No starch, no fillers, no mycelium fermented grain | Commonly contains grain (rice, oats or sorghum), starch and/or maltodextrin |
| Transparency | Full disclosure of ingredients, sourcing, testing and extraction | Vague or misleading marketing and unclear labeling |
| Cost per Serving | Cost-effective for active compounds concentration in every serving | Very expensive for amount of active compounds present |
| Expertise | 50+ years of mushroom cultivation expertise — leader in supplement industry quality & standards | Mislead customers with ambiguous labeling and filler-heavy products |
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Take the guesswork out of your mushroom supplement.
Start enjoying real results now.
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100% organic mushroom extracts
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Verified beta-glucans
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No grain fillers
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50 years of experience
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Wellness backed by 40,000+ customers
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CiCi T. As well as the five defenders, I take cordyceps and lions mane. I was diagnosed with chronic lymes and it was debilitating me. I had cardiac involvement as well as severe mobility issues. Within one week of starting the mushrooms all cardiac symptoms disappeared, and my mobility improved dramatically. These mushrooms have been a lifeline for me. Thank you!
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Helen I consumed the five defender and Cordycept mushroom supplements for a month. My allergies symptoms disappeared because I used to sneeze in the morning. Also, I can see my immune system getting better. This product is way better than the regular mushroom supplement. Superb quality as it said
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Pari M. I've suffered neuropathy in my hands for many years. I started taking the 5 Defenders blend because I thought it would be good overall for my health. I continued for about 6 months then stopped because of financial reasons. I hadn't noticed that my neuropathy had significantly reduced until about a month after stopping the 5 Defenders when it returned. I've restarted 5 Defenders and after 2-3 months the neuropathy is almost gone (again). I hope I never have to stop taking 5 Defenders because not only is it good overall but it also helps with my hand neuropathy. YAY!
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Lamont R. It helps me feel well and more alive
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Milton t.G.H. After a canine nutrition consultant suggested starting turkey tail for my 8-year-old boxer Milton, I started taking real mushrooms also. Instantly I noticed I had better gut health and sleep. Milton lived to be 11 years old and I attribute that to his homemade diet and use of mushrooms for immunity. I now take five defenders every 3 days and can always tell a difference in my sleep if I forget to take them. I have noticed that I don't get sick and I have better stamina as well as vision in my eyes. I appreciate the quality and consistency over other brands and I'm thankful I found real mushrooms.
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Frequently Asked Questions
All our mushroom extracts are from the leading supplier of organic mushroom extracts: Nammex. They have over 40 years of mushroom growing experience and were one of the first companies to bring organic functional mushroom extracts to North America.
Their ingredients go through rigorous quality control and are tested twice for heavy metals, agricultural chemicals and microbial contamination to ensure they meet all standards for dietary supplements of this nature. All of their extracts are made from certified organic mushrooms (fruiting bodies), organically grown or wildcrafted from deep within mountain regions of China.
Mushrooms used for dietary supplements are seldom grown in North America since they are too expensive. China is the leading supplier of mushrooms worldwide and supplies over 90% of the world’s mushrooms.
It has a rich history of mushroom use as both food and medicine and is the birthplace of mushroom cultivation, with shiitake being farmed in the early 1200s. China is one of the only places in the world where you can get 100% organic mushroom (fruiting body) extracts that can be sold at an affordable price.
The products are identical. The only difference is how you want to consume them.
2 capsules is equivalent to roughly a 1/2 tsp of the mushroom powders.
In terms of potency and efficacy, both the capsules and powders are equally effective at delivering.
The capsules are great for travel, whereas the powder can be added to recipes or mixed in coffee, tea or bone broth.
It is extremely important to distinguish the difference between mushrooms and mycelium.
Mushrooms are the "fruit" and reproductive stage of these organisms, while the mycelium is the root system or "body" of the fungus.
Mushrooms contain much higher levels of active compounds like beta-glucans, and there is a large body of research on them. They have also been consumed for thousands of years as food, and many health benefits have been shown from just mushroom consumption.
Mycelium is commonly grown on a grain substrate, and this grain cannot be separated from the mycelium, so much of the final product is actually grain with no mushrooms present. This shows up in high amounts of starch and low amounts of active compounds like beta-glucans.
For these reasons, Real Mushrooms® only utilizes mushrooms in all of its products, with verified levels of important active compounds like beta-glucans, and is always guarded against starchy fillers like grain.
5 Defenders® is a blend of organic mushroom extracts designed to help support overall well-being, resilience, and immune system health.
5 Defenders® is where most customers begin with Real Mushrooms®.
While single-mushroom supplements can be helpful for targeted needs, they often address just one slice of the wellness picture. Real Mushrooms®' 5 Denfenders® blend, however, supports:
- Innate and adaptive immune function
- Oxidative stress resilience
- Calm, balanced energy
- Gut and microbiome health (through Turkey Tail's prebiotic-like effects)
The blend is derived from 100% organic mushrooms, not myceliated grain, so you get potency without compromise: no starch, no fillers, just the active compounds your body can actually use.
5 Defenders® is a blend of extract powders consisting of:
- 30% Turkey Tail Mushroom
- 20% Reishi Mushroom
- 20% Shiitake Mushroom
- 20% Maitake Mushroom
- 10% Chaga
Natural ingredients don’t always flow smoothly through processing equipment, and capsule manufacturers need to utilize other ingredients to fill capsules. It is common practice for encapsulation facilities to require the use of other ingredients.
We have worked closely with our encapsulation partners to ensure that only what is added is necessary to create the mushroom capsules.
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