29 reviews
Ergo+ Ergothioneine Supplement
Longevity & Skin†
Size
60 Capsules
Quantity
100% Satisfaction • Fast Free Shipping $75+ • Secure Checkout
Ergo+ delivers L-ergothioneine, a rare antioxidant amino acid found in mushrooms and absorbed by a unique transporter in your body. Supplementing may support healthy aging, cognitive clarity, and resilience to oxidative stress.† Sourced from golden oyster mushrooms and fermentation, Ergo+ offers pure, effective support for long-term wellness.
Whether you're looking to stay sharp as you age or give your cells extra support against environmental stresses, our Ergo+ capsules offer a simple, effective way to nourish your body at the cellular level.
Our formula delivers a pure, concentrated source of L-ergothioneine, an amino acid antioxidant your body can’t make, but is built to absorb.
Real Mushrooms Ergo+ contains no mycelium, grain, or unnecessary fillers, just clean, verified ingredients designed to support long-term wellness.
Research-backed benefits of L-ergothioneine:†
- Supports healthy cognitive function and mental clarity
- Promotes antioxidant defenses against oxidative stress
- Helps maintain cellular health as you age
- Supports overall well-being and resilience
- Backed by emerging human research on healthy aging and neuroprotection
Take 1 capsule daily with or without food, or as recommended by your healthcare professional.
Many customers find it easiest to incorporate Ergo+ into their morning wellness routine, paired with other Real Mushrooms best-sellers like Lion’s Mane or Reishi.
Real Mushrooms products are always:
- Rated the #1 Mushroom brand by ConsumerLab
- Made from USDA Certified Organic Mushrooms
- Verified for active compounds, safety, & purity through third-party testing
- Purity-IQ verified for authenticity using nuclear magnetic resonance
- Free of grains, starches, and fillers
- Sourced from mushroom (fruiting bodies) only—never mycelium fermented grain
- Produced in a Good Manufacturing Practices (GMP)-compliant facility
This is our Real Mushrooms Guarantee: no shortcuts, no gimmicks—just real mushrooms.
Real Ingredients
An Amino Acid for Healthy Aging & Healthy Cognition
L-ergothioneine is a rare antioxidant amino acid found naturally in mushrooms, our richest source. Though our bodies can’t produce it, we’ve evolved a specific transporter to absorb and retain it, underlining its importance in human health. Research shows ergothioneine levels decline with age, and maintaining them may support cognitive health, cellular resilience, and healthy aging.
Ergo+ delivers a clean, natural source of L-ergothioneine from golden oyster mushrooms to help promote mental clarity and long-term well-being.
Real Mushrooms, Not Filler
Most mushroom supplements fail because they’re made without mushrooms: they use mycelium fermented grain. Those products have few beneficial fungal compounds—they’re mostly starch.
We use 100% hot water-extracted mushrooms (fruiting body) to unlock the true full spectrum of beneficial compounds.
Highest-Quality, Organic Ingredients
We partner with experienced mushroom growers using Di Dao 地道 (spiritual homeland) cultivation practices to harvest mushrooms in their geo-authentic environments. Our Ergo+ contain only the real mushroom, grown, extracted, and tested with integrity.
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4-Time Winner
Best Mushroom Supplement Brand: ConsumerLab.com Survey
Trusted by wellness seekers and professionals alike, our mushroom supplements have earned the rating of Best Mushroom Supplement Products four years in a row by consumers in ConsumerLab.com Annual Supplement Survey.
†Ratings based on results of the 2025 ConsumerLab.com Survey of Supplement Users. More information.
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Real People. Real Results.†
★★★★★
“I have a condition that causes constant fatigue. After taking the Ergo + for a week or so, I started to feel a difference. I have more stamina through the day, and my mind feels clearer.”†
– Verified Customer
★★★★★
“I’ve only been taking it for a month - but I already noticed a difference in my memory.”†
– Verified Customer
★★★★★
“It added a sharpness and speed to my thinking and processing... At almost 70 it is a joy to have words come to mind easily, and if I've misplaced my keys the last place I put them down comes readily to mind. I love my mushrooms!”†
– Verified Customer
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Real Science
Real Mushrooms is built on 50+ years of mycological and mushroom growing expertise. Our founder’s roots trace back to the beginning of the functional mushroom category in North America. Today we continue to lead the industry in science-backed and effective mushroom supplements.
Every batch of 5-Defenders is lab-verified for beta-glucan content and free of unwanted fillers like starch or alpha-glucans from grain. This scientific transparency ensures that what’s on the label is exactly what’s in the bottle.
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Real Quality
Why Beta-Glucans Matter
Beta-glucans are the primary active compounds in Ergo+ mushrooms that support immune function.* Most mushroom products don’t list beta-glucan content, but we do.
Beta-Glucans indicate an authentic mushroom product versus myceliated grain products that contain high levels of starch (Alpha-Glucans) instead.
Real Mushrooms offer potency you can trust, in every capsule.
We use only 100% mushroom (fruiting body)—no grain, no mycelium, no fillers.
This product has received the Purity-IQ™ Authenticity Certification Program - a cutting-edge nuclear magnetic resonance technique that confirms we use the correct mushroom species and nothing else.
View our certification on Purity-IQ
Certified organic. Verified species identity. No shortcuts. Just clean, potent mushrooms—exactly as nature intended.
We partner with experienced mushroom growers using Di Dao 地道(spiritual homeland) cultivation practices to harvest mushrooms in their geo-authentic environments. Our mushroom Ergo+ extract contains only the real mushroom—grown, extracted, and tested with integrity.
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Real Mushrooms vs. Other Brands
Not all mushroom supplements are created equal. Real Mushrooms has set the standard for the most effective mushroom products because we have never compromised on quality. Here’s how Real Mushroom supplements compare with the other leading brands on the market.
| Real Mushrooms | Other Brands | |
|---|---|---|
| Mushroom Source | 100% organic mushrooms (fruiting bodies) | Mycelium fermented grain (starch) and fillers |
| Beta-Glucan Content | Guaranteed beta-glucans — every batch third party tested for identity, purity and potency | Typically low beta-glucans and not disclosed — may list total polysaccharides instead which includes any starches |
| Extraction Method | Hot water extracted or dual extracted for potency & optimal absorption | Improperly extracted or simply dried and ground |
| Filler-Free Guarantee | No starch, no fillers, no mycelium fermented grain | Commonly contains grain (rice, oats or sorghum), starch and/or maltodextrin |
| Transparency | Full disclosure of ingredients, sourcing, testing and extraction | Vague or misleading marketing and unclear labeling |
| Cost per Serving | Cost-effective for active compounds concentration in every serving | Very expensive for amount of active compounds present |
| Expertise | 50+ years of mushroom cultivation expertise — leader in supplement industry quality & standards | Mislead customers with ambiguous labeling and filler-heavy products |
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Take the guesswork out of your mushroom supplement.
Start enjoying real results now.
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100% organic mushroom extracts
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Verified beta-glucans
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No grain fillers
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50 years of experience
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Wellness backed by 40,000+ customers
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Deb S. I started taking the mushroom supplements in late December. After a few weeks I could feel the difference. The mental fog is lifting. I’m going to keep taking them to see just how much improvement they’ll make.
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Eric i absolutely love these real mushroom extracts!! without any fillers i see much better results than with other brands
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Donna Regular subscription
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Denise This is a refill to my subscription. Definitely seeing some good results with adding ERGO+ just after 60 days.
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A.B. Amazing
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Frequently Asked Questions
All our mushroom extracts are from the leading supplier of organic mushroom extracts: Nammex. They have over 40 years of mushroom growing experience and were one of the first companies to bring organic functional mushroom extracts to North America.
Their ingredients go through rigorous quality control and are tested twice for heavy metals, agricultural chemicals and microbial contamination to ensure they meet all standards for dietary supplements of this nature. All of their extracts are made from certified organic mushrooms (fruiting bodies), organically grown or wildcrafted from deep within mountain regions of China.
Mushrooms used for dietary supplements are seldom grown in North America since they are too expensive. China is the leading supplier of mushrooms worldwide and supplies over 90% of the world’s mushrooms.
It has a rich history of mushroom use as both food and medicine and is the birthplace of mushroom cultivation, with shiitake being farmed in the early 1200s. China is one of the only places in the world where you can get 100% organic mushroom (fruiting body) extracts that can be sold at an affordable price.
The products are identical. The only difference is how you want to consume them.
2 capsules is equivalent to roughly a 1/2 tsp of the mushroom powders.
In terms of potency and efficacy, both the capsules and powders are equally effective at delivering.
The capsules are great for travel, whereas the powder can be added to recipes or mixed in coffee, tea or bone broth.
It is extremely important to distinguish the difference between mushrooms and mycelium.
Mushrooms are the "fruit" and reproductive stage of these organisms, while the mycelium is the root system or "body" of the fungus.
Mushrooms contain much higher levels of active compounds like beta-glucans, and there is a large body of research on them. They have also been consumed for thousands of years as food, and many health benefits have been shown from just mushroom consumption.
Mycelium is commonly grown on a grain substrate, and this grain cannot be separated from the mycelium, so much of the final product is actually grain with no mushrooms present. This shows up in high amounts of starch and low amounts of active compounds like beta-glucans.
For these reasons, Real Mushrooms® only utilizes mushrooms in all of its products, with verified levels of important active compounds like beta-glucans, and is always guarded against starchy fillers like grain.
Ergothioneine is a sulfur-based amino acid. Amino acids are important compounds that help the body build proteins. Ergothioneine was discovered in 1909 by Charles Tanret, a French pharmacist and chemist.
This compound holds powerful antioxidant potential, helping to protect cells from oxidative damage. Certain mushrooms, including some of our products, are known to contain high levels of ergothioneine naturally.
Tanret was examining the ergot fungus, which had recently been responsible for destroying crops, and he discovered the compound by using a purification process. The amino acid name ergothioneine originates from this fungus. While the ergot fungus may damage crops, the amino acid it contains helps essential functions in the human body.
Ergo+ provides a natural source of L-ergothioneine, an amino acid studied for its role in supporting cognitive health and oxidative stress balance.* These benefits make it a standout among certain types of mushroom products on the market today for supporting healthy aging.
Natural ingredients don’t always flow smoothly through processing equipment and capsule manufacturers need to utilize other ingredients in order to fill capsules. It is common practise for encapsulation facilities to require the use of other ingredients.
We have worked closely with our encapsulation partners to make sure that only what is added is absolutely necessary to create the capsules.
Beta-glucans are naturally occurring polysaccharides found in mushrooms and are among the most studied compounds for their functional properties*. For this reason, we specifically measure beta-glucan levels on our products.
We do not believe in using polysaccharides as a measure of quality as they can be easily doctored using starch-like substances like grains.
Whether you’re training hard or just looking for more natural energy throughout your day, Cordyceps may help you feel more resilient, active, and ready to perform.
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