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Daily Calm Duo
Longevity & Cognition†
$59.93
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A simple way to help manage everyday stress and find calm. The Daily Calm Duo from Real Mushrooms® combines Lion’s Mane CALM with Reishi to support emotional well-being and immune health. A simple routine to fit into anytime of day to help you stay balanced, steady and clear without haze or sedation.
- Supports a calm and balanced mood*
- Promotes relaxed focus without drowsiness*
- Helps manage everyday stress*
- Supports overall mental and emotional wellness*
- 100% organic mushroom extracts, no fillers
Take 2 capsules of both Lion’s Mane CALM and Reishi daily to support a calm and balanced mindset. It can be taken in the morning or evening, depending on your routine.
Real Mushrooms products are always:
- Rated the #1 Mushroom brand by ConsumerLab
- Made from USDA Certified Organic Mushrooms
- Verified for active compounds, safety, & purity through third-party testing
- Purity-IQ verified for authenticity using nuclear magnetic resonance
- Free of grains, starches, and fillers
- Sourced from mushroom (fruiting bodies) only—never mycelium fermented grain
- Produced in a Good Manufacturing Practices (GMP)-compliant facility
This is our Real Mushrooms Guarantee: no shortcuts, no gimmicks—just real mushrooms.
100 Days
100 Days
Money-Back Guarantee
94,000+
94,000+
5 star reviews
50+ Years
50+ Years
Growing experience
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5-Time Winner
Best Mushroom Supplement Brand: ConsumerLab.com Survey
Trusted by wellness seekers and professionals alike, our mushroom supplements have earned the rating of Best Mushroom Supplement Products five years in a row by consumers in ConsumerLab.com Annual Supplement Survey.
†Ratings based on results of the 2025 ConsumerLab.com Survey of Supplement Users. More information.
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Real People. Real Results.†
★★★★★
"I love mushrooms and they are packed with vitamins that are good for your body. I was happy to find Lions Mane. I find I am much more alert since taking it and it makes me feel good that I am taking something that I know is good for me."†
– Verified Customer
★★★★★
“I’ve been taking Reishi for about 5 months and I feel younger! I move better, my blood pressure went down... I will never stop taking this product!”†
– Verified Customer
★★★★★
"The brain fog from 2 bouts with Covid are in the past. I've been taking a daily boost of Lion's Mane and the fog has lifted. I'm so grateful for this powerful, natural addition to a healthy diet... what a difference it's making!"†
– Verified Customer
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Real Science
Real Mushrooms is built on 50+ years of mycological and mushroom growing expertise. Our founder’s roots trace back to the beginning of the functional mushroom category in North America. Today we continue to lead the industry in science-backed and effective mushroom supplements.
Every batch of 5-Defenders is lab-verified for beta-glucan content and free of unwanted fillers like starch or alpha-glucans from grain. This scientific transparency ensures that what’s on the label is exactly what’s in the bottle.
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Real Quality
Why Beta-Glucans Matter
Beta-glucans are the primary active compounds in mushrooms that support immune function.† Most mushroom products don’t list beta-glucan content in the Supplement Facts panel, but we do.
Beta-Glucan testing proves that a mushroom supplement is made with actual mushrooms and not diluted with grains or fillers. High levels of Beta-glucans per mushroom species indicate high purity and potency, versus mycelium-fermented grain products that contain high levels of grain starch instead.
Real Mushrooms products offer potency you can trust, in every serving.
We use only 100% mushroom (fruiting body)—no grain, no mycelium, no fillers.
This product has received the Purity-IQ™ Authenticity Certification Program - a cutting-edge nuclear magnetic resonance technique that confirms we use the correct mushroom species and nothing else.
View our certification on Purity-IQ
Certified organic. Verified species identity. No shortcuts. Just clean, potent mushrooms—exactly as nature intended.
We partner with experienced mushroom growers using Di Dao 地道(spiritual homeland) cultivation practices to harvest mushrooms in their geo-authentic environments. Our mushroom extract contains only the real mushroom—grown, extracted, and tested with integrity.
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Real Mushrooms vs. Other Brands
Not all mushroom supplements are created equal. Real Mushrooms has set the standard for the most effective mushroom products because we have never compromised on quality. Here’s how Real Mushroom supplements compare with the other leading brands on the market.
Real Mushrooms
100% organic mushrooms
Guaranteed >30% beta-glucans
Hot water extracted or dual extracted
No starch · no fillers
Full disclosure of ingredients, sourcing, testing and extraction
Cost-effective for active compound concentration in every serving
50+ years mushroom cultivation expertise
Other Brands
Mycelium fermented grain (starch + fillers)
Typically low, often undisclosed
Improperly extracted or simply dried and ground
Commonly contains rice, oats or sorghum starch and/or maltodextrin
Vague or misleading marketing and unclear labeling
Very expensive for amount of active compounds actually present
Mislead customers with ambiguous labeling and filler-heavy products
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Take the guesswork out of your mushroom supplement.
Start enjoying real results now.
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100% organic mushroom extracts
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Verified beta-glucans
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No grain fillers
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50 years of experience
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Wellness backed by 40,000+ customers
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Yes. Unlike traditional calming herbs or sleep aids, Lion’s Mane Calm supports calm clarity without causing drowsiness.
Lion’s Mane CALM is designed as a daily, long-term support formula:
- L-theanine supports ongoing calm with continued use
- Lion’s Mane provides cumulative nervous system support
This makes it suitable as part of a long-term wellness routine, not just occasional use.
This product is ideal for individuals who:
- Want calm without drowsiness
- Experience daily cognitive or emotional load
- Are looking for a non-sedating alternative to traditional calming supplements
It is also particularly relevant for individuals navigating life-stage transitions associated with increased stress, cognitive load, and/or irritability and moodiness.
Lion’s Mane supports long-term nervous system resilience, while L-theanine provides a more immediate calming effect.
Together, they create:
- Faster perceived benefits
- Deeper, cumulative support over time
This reflects the principle that combination formulas provide broader, more functional support than single ingredients.
No. This product is not a sedative.
It is designed to support calm alertness, similar to how practices like meditation promote relaxation while maintaining awareness.
L-theanine was chosen because it supports:
- Relaxation without sedation
- A calm but alert mental state (often described as “calm clarity”)
- Measurable changes in brainwave activity associated with relaxed focus
This aligns with modern demand for calm without mental fog.
Choose our Reishi mushroom supplements to incorporate traditionally valued functional mushrooms into your daily routine. Our extracts are carefully produced to ensure they are rich in beneficial compounds, offering a reliable, effective solution for those looking to integrate these health benefits into their daily routine.
Our organic Reishi capsules and extract powders are made with zero fillers, starch, or mycelium fermented grain. They are extracted and third-party tested for the highest potency and purity. These measures ensure you get a high-quality mushroom supplement with a full spectrum of easy-to-digest nutrients & active compounds.
Reishi mushrooms contain bioactive compounds that have been studied for their potential role in overall wellness and vitality*. This fungus contains over 400 different bioactive compounds, including triterpenoids, polysaccharides, nucleotides, sterols, steroids, fatty acids, proteins, peptides, and trace elements.
They contain hundreds of bioactive compounds, mainly in the form of polysaccharides and triterpenes, that assist the body in numerous ways.
Some of the research-supported benefits of Reishi include:*
- Supports immune health and resilience
- Supports mood and emotional well-being
- Promotes restful sleep and relaxation
- Supports energy, vitality, and healthy aging
- Helps maintain general wellness and resilience to stress
- Promotes cardiovascular and circulatory health
- Helps maintain healthy blood sugar metabolism
- Supports liver health
- Provides antioxidant support
- Promotes healthy inflammatory response
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