Skip to content
Pickup options

Lions Mane Mushroom Extracts

We bring you Lion’s Mane supplements that honor the ancient wisdom and modern science behind this remarkable mushroom. Lion’s Mane is a favorite for those looking to nourish their brain and body naturally.

A bottle of Real Mushrooms Lion's Mane Calm contains 90 capsules with Lion's Mane, Reishi, and L-theanine for calm clarity and balanced wellness.
A bottle of Real Mushrooms Lion's Mane Calm sits on a counter beside two capsules, a glass of water, and a bowl of peaches.
New
A brown bottle labeled "Real Mushrooms Lion's Mane Focus" contains 90 capsules of Lion’s Mane with cordyceps and Alpha-GPC, designed as a dietary supplement to support cognitive function.
A bottle of Real Mushrooms Lion's Mane Focus sits on a countertop next to a glass of water, two capsules, and a small stack of books.
New
A white "Real Mushrooms" bottle labeled "Organic Lion's Mane Extract Capsules, 120 count," featuring organic mushrooms and beta-glucans as a dietary supplement for cognition.
Someone pours two Organic Lion's Mane Extract Capsules by Real Mushrooms into their hand beside a glass of water on the kitchen counter, highlighting support for brain health.
Best Seller
A brown and cream pouch labeled "Real Mushrooms Lion’s Mane Mushroom Powder" offers 60 servings (60g), is USDA Organic certified, and highlights organic Lion’s Mane for cognition and immune support.
Someone adds Real Mushrooms Lion’s Mane Mushroom Powder, a brain health supplement, to a cup next to a bowl of granola topped with raspberries and blueberries on a table.
A white bottle labeled "Organic Lion's Mane Extract Capsules for Pets" by Real Mushrooms, an organic supplement for dogs and cats with 120 capsules rich in beta-glucans to support cognitive health.
A person pours Real Mushrooms Organic Lion's Mane Extract Capsules for Pets into their hand as a curious dog looks up, intrigued by the supplement’s rich beta-glucans.
A bottle of Real Mushrooms RealClarity dietary supplement with 60 capsules, featuring Lion's Mane, Ashwagandha, Rhodiola, Bacopa, and organic mushroom extract.
A person pours Real Mushrooms RealClarity capsules, containing Lion's Mane, Ashwagandha, Rhodiola, and Bacopa, into their hand next to a glass of water.
The Real Mushrooms Daily Calm Duo includes Lion’s Mane CALM for emotional well-being and Reishi Mushroom Extract Powder, with 90 capsules in each bottle.
The Daily Calm Duo by Real Mushrooms, featuring Lion’s Mane CALM and Reishi Mushroom Extract Powder (90 capsules each), is displayed on a countertop to support emotional well-being.
25% Off
The Real Mushrooms Daily Calm Trio—ERGO+, Lion’s Mane CALM, and Reishi—is displayed side by side against a brown background, highlighting this wellness supplement set.
Three bottles of Real Mushrooms’ Daily Calm Trio are displayed on a kitchen counter with fruit and kitchen items in the background.
25% Off
The Focus Power Duo by Real Mushrooms is displayed against a brown background—formulated with Cordyceps and Lion’s Mane to help support mental performance.
The Real Mushrooms Focus Power Duo, known for supporting mental performance, features two supplement bottles placed side by side on a kitchen countertop.
25% Off
The Focus Power Trio by Real Mushrooms—three supplements arranged side by side against a brown background—supports brain health and mental performance with ingredients like Lion’s Mane.
The Focus Power Trio by Real Mushrooms—ERGO, Lion’s Mane FOCUS, and Cordyceps-M—are displayed on a marble surface in warm lighting.
25% Off
The Real Mushrooms Calm Ritual Duo, featuring Mushroom Hot Chocolate Mix and Lion’s Mane CALM capsules, is displayed together against a brown background—ideal for enjoying calm clarity.
A Calm Ritual Duo from Real Mushrooms, featuring Mushroom Hot Chocolate Mix and Lion’s Mane CALM capsules, rests on a beige surface.
25% Off

Lions Mane Mushroom Extracts FAQs

All our mushroom extracts are from the leading supplier of organic mushroom extracts: Nammex. They have over 40 years of mushroom growing experience and were one of the first companies to bring organic functional mushroom extracts to North America.

Their ingredients go through rigorous quality control and are tested twice for heavy metals, agricultural chemicals and microbial contamination to ensure they meet all standards for dietary supplements of this nature. All of their extracts are made from certified organic mushrooms (fruiting bodies), organically grown or wildcrafted from deep within mountain regions of China.

Mushrooms used for dietary supplements are seldom grown in North America since they are too expensive. China is the leading supplier of mushrooms worldwide and supplies over 90% of the world’s mushrooms. 

It has a rich history of mushroom use as both food and medicine and is the birthplace of mushroom cultivation, with shiitake being farmed in the early 1200s. China is one of the only places in the world where you can get 100% organic mushroom (fruiting body) extracts that can be sold at an affordable price.

It is extremely important to distinguish the difference between mushrooms and mycelium.

Mushrooms are the "fruit" and reproductive stage of these organisms, while the mycelium is the root system or "body" of the fungus.

Mushrooms contain much higher levels of active compounds like beta-glucans, and there is a large body of research on them. They have also been consumed for thousands of years as food, and many health benefits have been shown from just mushroom consumption.

Mycelium is commonly grown on a grain substrate, and this grain cannot be separated from the mycelium, so much of the final product is actually grain with no mushrooms present. This shows up in high amounts of starch and low amounts of active compounds like beta-glucans. 

For these reasons, Real Mushrooms only utilizes mushrooms in all of its products, with verified levels of important active compounds like beta-glucans, and is always guarded against starchy fillers like grain.

Choose our Lion’s Mane mushroom supplements to incorporate traditionally valued functional mushrooms into your daily routine. Our extracts are carefully produced to ensure they are rich in beneficial compounds, offering a reliable, effective solution for those looking to integrate these health benefits into their daily routine.

Our organic Lion’s Mane capsules and extract powders are made with zero fillers, starch, or mycelium fermented grain. They are extracted and third-party tested for the highest potency and purity. These measures ensure you get a high-quality mushroom supplement with a full spectrum of easy-to-digest nutrients & active compounds.

Lion’s Mane is a functional mushroom long used to support overall wellness, especially brain and nerve health. Modern research suggests that Lion’s Mane may help support:

  • Mental clarity and focus
  • Healthy brain aging
  • Healthy mood and emotional well-being
  • Relaxation and healthy sleep patterns
  • Nerve and gut health

Its naturally occurring compounds, such as hericenones and beta-glucans, are believed to play a key role in these effects. Hericenones are unique to the mushroom fruiting body and are being studied for their ability to support the brain’s production of nerve growth factor (NGF), a protein essential to healthy nerve cell function.

At Real Mushrooms, we only use 100% organic Lion’s Mane mushrooms (fruiting body only), not mycelium grown on grain. Our extracts are hot water extracted and tested to ensure they contain meaningful levels of active compounds like beta-glucans, which many grain-based products lack. This ensures you're getting a pure, potent product that delivers the benefits Lion’s Mane is known for, without unwanted starches or fillers.

Whether you're looking to support long-term brain health, improve focus, or simply stay sharp, Lion’s Mane can be a valuable addition to your wellness routine.

Lion’s Mane is a functional mushroom known for its potential to support brain health, concentration, and focus. There has also been research in adults with mild memory problems associated with aging that found that those taking Lion’s Mane mushroom powder had improved memory function compared with control participants who did not ingest the mushroom.

Compounds naturally found in Lion’s Mane, such as hericenones and beta-glucans, have been studied for their role in supporting the brain’s natural production of nerve growth factor (NGF), which helps maintain healthy nerve cells.

While Lion’s Mane shows promising potential for cognitive support, it’s important to understand that not all Lion’s Mane supplements are created equal. Many products on the market are made from mycelium fermented grain, which often contain high levels of starch from the growing substrate and very little of the mushroom’s active compounds.

At Real Mushrooms, we use 100% organic Lion’s Mane mushrooms (fruiting bodies only), not mycelium and not grain. Our products are hot water extracted and third-party tested to ensure they contain significant levels of key compounds, including:

  • Beta-glucans (the active polysaccharides that help support immune and cognitive function)
  • Hericenones, unique to the mushroom fruiting body and studied for their impact on neurological health

This difference in quality and composition can have a big impact on whether you’re truly getting the benefits Lion’s Mane is known for. When choosing a supplement for cognitive support, look for one that clearly discloses beta-glucan content and uses only the real mushroom, not grain or filler.

5-Time Winner

Best Mushroom Supplement Brand: ConsumerLab.com Survey

Trusted by wellness seekers and professionals alike, our mushroom supplements have earned the rating of Best Mushroom Supplement Products four years in a row by consumers in ConsumerLab.com Annual Supplement Survey.

†Ratings based on results of the 2025 ConsumerLab.com Survey of Supplement Users. More information.

Mushrooms for Whole Health

5 products

Rest and Relaxation

Shop Now

Person rolling up a green yoga mat in a bright room with natural light.

4 products

Cognition and Focus

Shop Now

Two elderly people playing chess outdoors

6 products

Immunity

Shop Now

A woman giving her young daughter a kiss

12 products

Pet Health

Shop Now

Man sitting by a lake with a dog, both looking at something on the ground.