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Immune Power
Immunity†
$56.17
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The Immune Power bundle combines two of our most trusted mushroom supplements: 5 Defenders and Ergo+ for simple, daily wellness support. This duo offers high-quality beta-glucans and the rare antioxidant L-ergothioneine. It’s an easy and effective way to support your health routine with real, science-backed mushroom nutrition.
- Convenient daily support with two synergistic mushroom formulas
- Made from 100% organic mushroom (fruiting body) extracts
- No grains, no fillers—just pure, high-quality ingredients you can trust
5 Defenders
Take 2 capsules daily with or without food. Can be taken any time of day.
Ergo+
Take 1 capsule daily with or without food. Best taken consistently as part of your daily routine.
Real Mushrooms products are always:
- Rated the #1 Mushroom brand by ConsumerLab
- Made from USDA Certified Organic Mushrooms
- Verified for active compounds, safety, & purity through third-party testing
- Purity-IQ verified for authenticity using nuclear magnetic resonance
- Free of grains, starches, and fillers
- Sourced from mushroom (fruiting bodies) only—never mycelium fermented grain
- Produced in a Good Manufacturing Practices (GMP)-compliant facility
This is our Real Mushrooms Guarantee: no shortcuts, no gimmicks—just real mushrooms.
4-Time Winner
Best Mushroom Supplement Brand: ConsumerLab.com Survey
Trusted by wellness seekers and professionals alike, our mushroom supplements have earned the rating of Best Mushroom Supplement Products four years in a row by consumers in ConsumerLab.com Annual Supplement Survey.
†Ratings based on results of the 2025 ConsumerLab.com Survey of Supplement Users. More information.
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Real People. Real Results.†
★★★★★
"Every morning I start off with 5 Defenders as breakfast with my coffee. I love this product, have been taking it for longer than a year and fully believe it's helping. Thanks!"
-Verified Customer
★★★★★
"I really love these and the convenience of taking them in pill form."
-Verified Customer
★★★★★
"I have high Cholesterol and immediately I notice a difference in my body...something in me got more stable and Healthy...no other words to describe it."
-Verified Customer
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Real Science
Real Mushrooms is built on 50+ years of mycological and mushroom growing expertise. Our founder’s roots trace back to the beginning of the functional mushroom category in North America. Today we continue to lead the industry in science-backed and effective mushroom supplements.
Every batch of 5-Defenders is lab-verified for beta-glucan content and free of unwanted fillers like starch or alpha-glucans from grain. This scientific transparency ensures that what’s on the label is exactly what’s in the bottle.
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Real Quality
Why Beta-Glucans Matter
Beta-glucans are the primary active compounds in mushrooms that support immune function.† Most mushroom products don’t list beta-glucan content in the Supplement Facts panel, but we do.
Beta-Glucan testing proves that a mushroom supplement is made with actual mushrooms and not diluted with grains or fillers. High levels of Beta-glucans per mushroom species indicate high purity and potency, versus mycelium-fermented grain products that contain high levels of grain starch instead.
Real Mushrooms products offer potency you can trust, in every serving.
We use only 100% mushroom (fruiting body)—no grain, no mycelium, no fillers.
This product has received the Purity-IQ™ Authenticity Certification Program - a cutting-edge nuclear magnetic resonance technique that confirms we use the correct mushroom species and nothing else.
View our certification on Purity-IQ
Certified organic. Verified species identity. No shortcuts. Just clean, potent mushrooms—exactly as nature intended.
We partner with experienced mushroom growers using Di Dao 地道(spiritual homeland) cultivation practices to harvest mushrooms in their geo-authentic environments. Our mushroom extract contains only the real mushroom—grown, extracted, and tested with integrity.
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Real Mushrooms vs. Other Brands
Not all mushroom supplements are created equal. Real Mushrooms has set the standard for the most effective mushroom products because we have never compromised on quality. Here’s how Real Mushroom supplements compare with the other leading brands on the market.
| Real Mushrooms | Other Brands | |
|---|---|---|
| Mushroom Source | 100% organic mushrooms (fruiting bodies) | Mycelium fermented grain (starch) and fillers |
| Beta-Glucan Content | Guaranteed beta-glucans — every batch third party tested for identity, purity and potency | Typically low beta-glucans and not disclosed — may list total polysaccharides instead which includes any starches |
| Extraction Method | Hot water extracted or dual extracted for potency & optimal absorption | Improperly extracted or simply dried and ground |
| Filler-Free Guarantee | No starch, no fillers, no mycelium fermented grain | Commonly contains grain (rice, oats or sorghum), starch and/or maltodextrin |
| Transparency | Full disclosure of ingredients, sourcing, testing and extraction | Vague or misleading marketing and unclear labeling |
| Cost per Serving | Cost-effective for active compounds concentration in every serving | Very expensive for amount of active compounds present |
| Expertise | 50+ years of mushroom cultivation expertise — leader in supplement industry quality & standards | Mislead customers with ambiguous labeling and filler-heavy products |
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Take the guesswork out of your mushroom supplement.
Start enjoying real results now.
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100% organic mushroom extracts
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Verified beta-glucans
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No grain fillers
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50 years of experience
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Wellness backed by 40,000+ customers
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5 Defenders® is a blend of organic mushroom extracts designed to help support overall well-being, resilience, and immune system health.
It is the product that most new customers begin with Real Mushrooms®.
While single-mushroom supplements can be helpful for targeted needs, they often address just one slice of the wellness picture. Real Mushrooms' 5 Defenders® blend, however, supports:
- Innate and adaptive immune function†
- Oxidative stress resilience†
- Calm, balanced energy†
- Gut and microbiome health (through Turkey Tail's prebiotic-like effects)†
The blend is derived from 100% organic mushrooms, not mycelium fermented grain, so you get potency without compromise: no starch, no fillers, just the active compounds your body can actually use.
Ergothioneine is a sulfur-based amino acid. Amino acids are important compounds that help the body build proteins. Ergothioneine was discovered in 1909 by Charles Tanret, a French pharmacist and chemist.
This compound holds powerful antioxidant potential, helping to protect cells from oxidative damage. Certain mushrooms, including some of our products, are known to contain high levels of ergothioneine naturally.
Tanret was examining the ergot fungus, which had recently been responsible for destroying crops, and he discovered the compound by using a purification process. The amino acid name ergothioneine originates from this fungus. While the ergot fungus may damage crops, the amino acid it contains helps essential functions in the human body.
All our mushroom extracts are from the leading supplier of organic mushroom extracts: Nammex. They have over 40 years of mushroom growing experience and were one of the first companies to bring organic functional mushroom extracts to North America.
Their ingredients go through rigorous quality control and are tested twice for heavy metals, agricultural chemicals and microbial contamination to ensure they meet all standards for dietary supplements of this nature. All of their extracts are made from certified organic mushrooms (fruiting bodies), organically grown or wildcrafted from deep within mountain regions of China.
Mushrooms used for dietary supplements are seldom grown in North America since they are too expensive. China is the leading supplier of mushrooms worldwide and supplies over 90% of the world’s mushrooms.
It has a rich history of mushroom use as both food and medicine and is the birthplace of mushroom cultivation, with shiitake being farmed in the early 1200s. China is one of the only places in the world where you can get 100% organic mushroom (fruiting body) extracts that can be sold at an affordable price.
The products are identical. The only difference is how you want to consume them.
2 capsules is equivalent to roughly a 1/2 tsp of the mushroom powders.
In terms of potency and efficacy, both the capsules and powders are equally effective at delivering.
The capsules are great for travel, whereas the powder can be added to recipes or mixed in coffee, tea or bone broth.
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