What Are The Side Effects Of Cordyceps Mushrooms?

What Are The Side Effects Of Cordyceps Mushrooms? cover
Written by Skye Chilton - Updated: March 14, 2025

Cordyceps mushrooms, a type of parasitic fungus used in ancient Chinese herbal medicine for centuries, have gained popularity due to their potential health benefits. However, like any supplement, cordyceps mushrooms may cause side effects in some individuals. Understanding these potential side effects is crucial for consumers to make informed decisions about their use.

This article explores the possible side effects associated with cordyceps mushrooms, addressing common concerns and providing insights into their safety profile.

In This Article

  1. What Are the Common Side Effects of Cordyceps Mushrooms?
  2. Are There Any Long-Term Side Effects?
  3. Can Cordyceps Mushrooms Cause Allergic Reactions?
  4. How Do Cordyceps Mushrooms Interact with Medications?
  5. Are There Any Side Effects for Pregnant or Breastfeeding Women?
  6. What Are the Side Effects of Taking High Doses?
  7. Understand Cordyceps Safety

What Are the Common Side Effects of Cordyceps?

While cordyceps mushrooms offer numerous health benefits, some individuals may experience mild digestive discomfort. Being aware of these side effects helps ensure safe usage.

Can Cordyceps Mushrooms Cause Digestive Issues?

Cordyceps mushrooms, including natural Cordyceps sinensis and Cordyceps militaris, have been traditionally used in various forms of Chinese traditional herbal medicines, with perceived health-improving properties. However, like many supplements, they may cause digestive issues in some individuals.

The most commonly reported digestive side effects include nausea, diarrhea, and stomach cramps. These symptoms can vary in intensity and duration, depending on the individual's sensitivity and the dosage consumed. [1]

Consuming the mushrooms with food may also help prevent gastrointestinal discomfort. Additionally, staying hydrated and monitoring one's diet can further alleviate symptoms.

Tip: To mitigate digestive issues, it is recommended to start with a low dose of cordyceps and gradually increase it, allowing the body to adjust.

Do Cordyceps Mushrooms Affect Energy Levels and Sleep Patterns?

Cordyceps mushrooms are often associated with increased energy levels and better athletic performance, which has led to their popularity as a natural Cordyceps supplement.

The active compounds in cordyceps, such as cordycepin, are believed to play a role in boosting energy by improving the efficiency of oxygen utilization and increasing ATP production, the primary energy carrier in cells. This effect can potentially lead to heightened stamina and reduced fatigue, making cordyceps a favored choice among athletes and individuals seeking to improve endurance exercise performance. [2]

However, the impact of cordyceps on sleep patterns is less straightforward. While some users report increased alertness and energy, others may experience disturbances in their sleep cycle.

To mitigate potential sleep disturbances, it is generally recommended to consume cordyceps earlier in the day. This timing allows the body to utilize the energy-supporting effects during waking hours and reduces the likelihood of interference with nighttime rest.

Are There Any Long-Term Side Effects?

realboost mushroom and herbs supplement bottle on wood planks
RealBoost from Real Mushrooms contains Cordyceps and other herbs to support healthy energy levels.

Cordyceps mushrooms are generally considered safe when used in moderation, but questions remain about their long-term effects. Understanding the potential risks associated with prolonged use is essential for making informed decisions about supplementation.

How Do Cordyceps Mushrooms Affect Blood Sugar Levels?

Cordyceps mushrooms have been studied for their potential assistance in maintaining normal blood sugar levels. These fungi are believed to influence glucose metabolism, which may benefit individuals seeking to regulate their blood sugar.

The primary mechanism by which cordyceps may affect blood sugar involves the support of insulin sensitivity and the modulation of glucose uptake in cells.

Research indicates that cordyceps may support healthy glucose metabolism and insulin function, as observed in preliminary studies, thereby improving the body's ability to utilize glucose efficiently.

This effect is particularly relevant for individuals with insulin resistance. Additionally, cordyceps are thought to stimulate the production of insulin by the pancreas, further aiding in the regulation of blood sugar levels. [3] [4]

The effects of cordyceps on blood sugar can vary based on dosage and individual health status. Individuals with insulin resistance should monitor their blood sugar levels closely and consult a healthcare professional before incorporating cordyceps into their regimen.

Health Tip: Maintain normal blood sugar by eating balanced meals with complex carbohydrates, lean protein, and healthy fats. Regular physical activity also helps improve insulin sensitivity and glucose control.

Are There Any Cardiovascular Side Effects Linked to Cordyceps Mushrooms?

While some studies suggest that cordyceps have been traditionally used to support cardiovascular function, and research suggests they may contribute to healthy circulation, there are also concerns about potential side effects.

One of the primary cardiovascular concerns associated with cordyceps mushrooms is their impact on blood pressure. Cordyceps has been studied for its potential role in supporting cardiovascular function and circulation. Individuals with blood pressure concerns should speak with their healthcare provider.

The impact on blood pressure could be beneficial for individuals with hypertension; however, it may pose risks for those with already low blood pressure or those taking medications that lower blood pressure, potentially leading to hypotension. [5] [6]

While this could be advantageous for some individuals, it may also interact with medications used to treat arrhythmias or blood thinners, necessitating caution and consultation with a healthcare provider.

shop cordyceps with man holding a cordyceps supplement bottle in the background

Can Cordyceps Mushrooms Cause Allergic Reactions?

symptom of allergic reaction to cordyceps side effects
Allergic reactions to Cordyceps may occur. There are a few common symptoms.

While allergic reactions to cordyceps mushrooms are considered relatively uncommon, they can occur in susceptible individuals.

The prevalence of such reactions is not well-documented in scientific literature, largely due to the limited number of studies specifically addressing the allergenic potential of cordyceps. However, as with any natural supplement, individual responses can vary significantly.

Symptoms of an allergic reaction to cordyceps can include:

  • Skin rashes or hives
  • Itching or swelling, particularly around the face or throat
  • Gastrointestinal discomfort, including nausea or diarrhea

Due to the potential for serious allergic reactions, it is advisable for individuals with known sensitivities to fungi to exercise caution when considering the use of cordyceps supplements. Healthcare providers may recommend starting with a small dose to monitor for any adverse reactions.

How Do Cordyceps Mushrooms Interact with Medications?

Cordyceps mushrooms, like many supplements, have the potential to interact with various medications, leading to a range of consequences. These interactions can alter the effectiveness of medications or exacerbate side effects, posing risks to individuals who are concurrently using pharmaceuticals.

One of the primary concerns is the interaction of cordyceps with immunosuppressive drugs. Cordyceps have been studied for their role in supporting immune function, but individuals taking immunosuppressive medications should consult their healthcare provider. Cordyceps may be supportive when used in organ transplant patients or individuals with autoimmune diseases like systemic lupus erythematosus. This antagonistic interaction could potentially lead to reduced efficacy of the immunosuppressive therapy. [7]

Additionally, cordyceps may interact with anticoagulants or antiplatelet medications. The potential for cordyceps to affect blood clotting mechanisms could enhance the effects of these medications, increasing the risk of bleeding complications.

Patients taking blood thinners such as warfarin, aspirin, or other blood-thinning agents should be particularly cautious and consult healthcare providers before incorporating cordyceps into their regimen.

Cordyceps may also influence the metabolism of certain drugs by affecting liver enzymes responsible for drug breakdown. This can lead to altered plasma levels of medications, either increasing the risk of toxicity or reducing therapeutic efficacy. [8]

Are There Any Side Effects for Pregnant or Breastfeeding Women?

Research on the safety of cordyceps mushrooms during pregnancy and breastfeeding is limited, and there is a lack of comprehensive clinical studies specifically addressing this topic. The primary concern with the use of cordyceps during pregnancy and breastfeeding is the potential transfer of bioactive compounds, which could affect the fetus or infant.

Given these uncertainties, healthcare professionals often advise pregnant and breastfeeding women to exercise caution and avoid the use of cordyceps unless specifically recommended by a healthcare provider. It is essential for pregnant women to consult with their healthcare providers before taking any supplements, including cordyceps, to ensure the safety of both the mother and the developing fetus.

Health Tip: Pregnant women should prioritize a nutrient-rich diet, stay hydrated, and get adequate rest to support their health and the baby’s development. Always consult a doctor before taking any supplements or making major dietary changes.

Possible Side Effects of Taking High Amounts of Cordyceps

Like many supplements, taking Cordyceps in high amounts may lead to mild digestive discomfort in some individuals. It is advisable to follow recommended dosage guidelines and consult a healthcare provider if unsure. While cordyceps are generally considered safe when consumed in moderate amounts, high doses may result in adverse reactions.

Some of the side effects associated with excessive intake of cordyceps include:

  1. Gastrointestinal disturbances
  2. Increased symptoms of autoimmune diseases
  3. Kidney and liver strain
  4. Hormonal imbalance

It is important for individuals considering the use of cordyceps mushrooms to adhere to recommended dosages and consult healthcare professionals, especially if they have underlying health conditions or are taking other medications. Monitoring for any adverse effects and adjusting intake accordingly can help mitigate the risks associated with excessive consumption.

Understand Cordyceps Safety

While cordyceps mushrooms are generally considered safe for most individuals, they may cause a range of side effects, including digestive issues, changes in energy levels and sleep patterns, and potential allergic reactions. Long-term effects and interactions with medications, particularly concerning blood sugar and cardiovascular health, warrant caution.

Understanding these potential side effects can help users make informed decisions about incorporating cordyceps mushrooms into their health regimen.

Ready to experience the natural energy and vitality of Cordyceps without the worry of side effects? Explore Real Mushrooms' premium selection, crafted from 100% mushrooms (fruiting body), and feel the difference today.

shop cordyceps with man holding a cordyceps supplement bottle in the background

Related Articles

References

  1. Cordyceps Mushrooms: A Superfood? (2023, February 10). Integris Health. Retrieved January 23, 2025, from https://integrishealth.org/resources/on-your-health/2023/february/cordyceps-mushrooms
  2. Hirsch, K. R., Smith-Ryan, A. E., Roelofs, E. J., Trexler, E. T., & Mock, M. G. (2016b). Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. Journal of Dietary Supplements, 14(1), 42–53. https://doi.org/10.1080/19390211.2016.1203386
  3. Liu, X., Dun, M., Jian, T., Sun, Y., Wang, M., Zhang, G., & Ling, J. (2023). Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites. Frontiers in Pharmacology, 14. https://doi.org/10.3389/fphar.2023.1134429
  4. Dong, Y., Jing, T., Meng, Q., Liu, C., Hu, S., Ma, Y., Liu, Y., Lu, J., Cheng, Y., Wang, D., & Teng, L. (2014). Studies on the antidiabetic activities of Cordyceps militaris Extract in Diet-Streptozotocin-Induced diabetic Sprague-Dawley rats. BioMed Research International, 2014, 1–11. https://doi.org/10.1155/2014/160980
  5. Wang, L., Sun, H., Yang, M., Xu, Y., Hou, L., Yu, H., Wang, X., Zhang, Z., & Han, J. (2022). Bidirectional regulatory effects of Cordyceps on arrhythmia: Clinical evaluations and network pharmacology. Frontiers in Pharmacology, 13. https://doi.org/10.3389/fphar.2022.948173
  6. Dworecka-Kaszak, B. (2014). Cordyceps fungi as natural killers, new hopes for Medicine and biological control factors. Annals of Parasitology, 60(3)–151–158.
  7. Das, G., Shin, H., Leyva-Gómez, G., Del Prado-Audelo, M. L., Cortes, H., Singh, Y. D., Panda, M. K., Mishra, A. P., Nigam, M., Saklani, S., Chaturi, P. K., Martorell, M., Cruz-Martins, N., Sharma, V., Garg, N., Sharma, R., & Patra, J. K. (2021b). Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials. Frontiers in Pharmacology, 11. https://doi.org/10.3389/fphar.2020.602364
  8. Liu, Y. (2003). Inhibitive effect of cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism. World Journal of Gastroenterology, 9(3), 529. https://doi.org/10.3748/wjg.v9.i3.529

.
Skye is the founder of Real Mushrooms. Read more about his story into medicinal mushrooms here. When he’s not spreading the word of Real Mushrooms, he enjoys mushroom foraging, bouldering, cooking, gardening and hiking.

Disclaimer: The information or products mentioned in this article are provided as information resources only, and are not to be used or relied on to diagnose, treat, cure, or prevent any disease. This information does not create any patient-doctor relationship, and should not be used as a substitute for professional diagnosis and treatment. The information is intended for health care professionals only. The statements made in this article have not been evaluated by the Food and Drug Administration. Any products mentioned are not intended to diagnose, treat, cure, or prevent any disease. The information in this article is intended for educational purposes. The information is not intended to replace medical advice offered by licensed medical physicians. Please consult your doctor or health practitioner for any medical advice.

chevron-down