Cordyceps Mushrooms for Muscle Growth: What Science Says

Cordyceps Mushrooms for Muscle Growth: What Science Says cover
Written by Skye Chilton - Updated: April 10, 2025

Cordyceps is a genus of fungi that includes over 400 species, but Cordyceps militaris and Cordyceps sinensis are the most commonly researched varieties. These mushrooms are a mainstay of traditional Chinese medicine, as well as other alternative and complementary medicine. They grow naturally on insect larvae in high-altitude regions but are now cultivated on plant-based substrates to make them more accessible. Cordyceps contain bioactive compounds like cordycepin, adenosine, and polysaccharides, which researchers are investigating for their potential health-supporting properties, including peak power output during physical exertion [3].

comparison between cordyceps sinensis and cordyceps militaris
Cordyceps mushrooms may provide support healthy muscle growth as well as endurance and energy.

Cordyceps militaris and sinensis have long been associated with energy enhancement and vitality in traditional medicine. In modern research, scientists are particularly interested in their effects on ATP production, oxygen utilization, adaptogenic properties, and their effect on human skeletal muscle and anaerobic performance [7]. While initial findings are promising, more studies are needed to fully validate their effectiveness for the growth of human skeletal muscle and athletic performance in conjunction with a normal diet and exercise routine [1].

In This Article

  1. The Role of Cordyceps in Energy and Endurance
  2. How Cordyceps Extract May Indirectly Support Muscle Growth
  3. The Impact of Cordyceps on Mitochondrial Function
  4. Cordyceps and Protein Metabolism
  5. Scientific Research on Cordyceps and Performance
  6. Final Thoughts

The Role of Cordyceps in Energy and Endurance

Athletes, fitness enthusiasts, and sports science researchers often seek natural ways to optimize endurance, energy levels, and recovery, especially after high-intensity exercise. Some research suggests that cordyceps may help support VO2 max, a measure of how efficiently the body uses oxygen during exercise [5]. Improved muscle tissue oxygen saturation can contribute to sustained endurance and delayed fatigue, potentially enhancing performance in aerobic activities like running, cycling, and swimming. Increased oxygen uptake also benefits overall cardiovascular health [4].

Adenosine triphosphate (ATP) is the primary energy currency of cells. Cordyceps contain adenosine and cordycepin, which are being explored for their role in supporting ATP production [2]. More efficient energy production may help athletes sustain longer and more intense workouts. By helping the body utilize energy more effectively, cordyceps may support overall stamina and endurance [7]. Enhanced ATP production translates to improved muscle function. Since energy availability is one of the main factors in muscle contractions, optimizing ATP levels through supplementation could positively impact aerobic capacity, endurance capacity, resistance training, and high-intensity exercise [1].

Strenuous physical activity generates oxidative stress, which can contribute to muscle fatigue. The polysaccharides and other bioactive compounds in Cordyceps have been investigated for their antioxidant properties, which may help support the body’s natural recovery processes after exercise [3]. By supporting the body's ability to manage oxidative stress, cordyceps supplements may play a role in post-workout recovery [4].

How Cordyceps Extract May Indirectly Support Muscle Growth

hands holding the bar with weights
Cordyceps may support healthy muscle growth by also supporting healthy endurance levels.

The healthy growth of muscle requires consistent resistance training and proper recovery. By helping sustain energy levels and reduce perceived fatigue, Cordyceps extract may support individuals in maintaining regular workouts, which is essential for building muscle over time [1]. A supplement that supports endurance and reduces perceived effort can help individuals train longer and with greater intensity [5]. Preliminary research suggests that cordycepin, one of the active compounds in cordyceps, may play a role in cellular function. While more studies are needed on mushroom benefits, researchers are investigating its potential influence on muscle maintenance and repair [2]. Cellular health is essential for overall muscle function and recovery [6].

Cordyceps extract is often classified as an adaptogen, which means it may help the body adapt to physical and environmental stressors. Adaptogens have been studied for their potential to support energy balance and resilience to stress [4]. By supporting stress management, cordyceps may contribute to overall well-being, which is important for recovery and sustained physical performance (6).

The Impact of Cordyceps on Mitochondrial Function

Mitochondria, often referred to as the powerhouses of the cell, play a crucial role in energy metabolism. Efficient mitochondrial function is essential for endurance, muscle contraction, and post-exercise recovery. Some studies indicate that cordyceps may enhance mitochondrial efficiency, leading to improved cellular respiration and energy output. A study published in Molecules explored how Cordyceps supplementation influenced mitochondrial activity in skeletal muscle cells. The findings suggested that certain bioactive compounds in Cordyceps supplementation could help optimize mitochondrial function, potentially leading to enhanced stamina and endurance [1].

Cordyceps and Protein Metabolism

Healthy muscle development is dependent on protein synthesis—the process by which the body builds new muscle proteins. While protein intake from diet remains the most critical factor, certain compounds in cordyceps may influence protein metabolism [2]. A study published in Food & Function investigated the effects of cordycepin, one of the key bioactive compounds in cordyceps, on protein synthesis pathways. The research suggested that cordycepin may help regulate signaling pathways associated with muscle repair and maintenance [3].

Scientific Research on Cordyceps and Performance

bottle of cordyceps supplement with cordyceps mushrooms on its side
Add Real Mushrooms Cordyceps capsules to your daily routine to support healthy energy and endurance levels.

Several studies have explored the potential benefits of cordyceps on physical performance. A study published in the Journal of Dietary Supplements found that individuals supplementing with cordyceps experienced improvements in exercise performance compared to a placebo group [1]. Research in Frontiers in Pharmacology highlighted cordyceps' antioxidant properties, suggesting they may support the body’s response to oxidative stress from intense exercise [2].

Final Thoughts

Cordyceps have gained attention for their potential role in supporting endurance performance, energy, and recovery—key factors that contribute to muscle development and a healthy body mass index [4]. While more research is needed to fully understand their benefits, current studies suggest that cordyceps supplementation may be a valuable addition to a well-rounded fitness and nutrition plan [1].

As with any supplement, consistency, proper training, and balanced nutrition remain the most important factors for achieving overall performance goals. If you are considering cordyceps for athletic support, consult with a healthcare professional to determine whether they align with your individual health and fitness goals. By taking a holistic approach to training and wellness, you can optimize your potential for strength, endurance, recovery, and a healthy body weight.

shop cordyceps

Related Articles

  1. How Traditional Chinese Medicine uses Cordyceps
  2. Cordyceps Mushrooms: Supplement Types & Health Benefits
  3. Cordyceps Mushrooms for Energy: A Natural Approach to Sustaining Vitality

References

  1. Dudgeon, W. D., Thomas, D. D., Dauch, W., Scheett, T. P., & Webster, M. J. (2021). The effects of high and low-dose Cordyceps militaris-containing mushroom blend supplementation after seven and twenty-eight days. Frontiers in Pharmacology, 11, 602364. https://doi.org/10.3389/fphar.2020.602364
  2. Das, G., Shin, H. S., Leyva-Gómez, G., Del Prado-Audelo, M. L., Cortes, H., Singh, Y. D., Panda, M. K., Mishra, A. P., Nigam, M., Saklani, S., Chaturi, P. K., Martorell, M., Cruz-Martins, N., Sharma, V., Garg, N., Sharma, R., & Patra, J. K. (2021). Cordyceps spp.: A review on its immune-stimulatory and other biological potentials. Frontiers in Pharmacology, 11, 602364. https://doi.org/10.3389/fphar.2020.602364
  3. Yuan, Q., Xie, F., Tan, J., Yuan, Y., Mei, H., Zheng, Y., & Sheng, R. (2022). Extraction, structure and pharmacological effects of the polysaccharides from Cordyceps sinensis: A review. Journal of Functional Foods, 89, 104909. https://doi.org/10.1016/j.jff.2022.104909
  4. Jung, S. J., Jung, E. S., Choi, E. K., Sin, H. S., Ha, K. C., & Chae, S. W. (2015). Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepialia; CBG-CS-2): A randomized and double-blind clinical trial. Journal of Ethnopharmacology, 159, 215–221. https://doi.org/10.1016/j.jep.2014.11.026
  5. Jeng, K. C., Huang, K. J., Lee, Y. E., Hou, C. W., Chen, K. H., & Hung, M. S. (2009). Effect of Rhodiola rosea and Cordyceps sinensis on exercise performance and skeletal muscle injury in rats. Phytotherapy Research, 23(8), 1128–1132. https://doi.org/10.1002/ptr.2761
  6. Irani, M., Amirian, M., Sadeghi, R., Lez, J. L., & Latifnejad Roudsari, R. (2021). A review of foods and food supplements increasing testosterone levels. Journal of Men's Health, 17(4), 1550–1555. https://doi.org/10.31083/jomh.2021.008
  7. Ji, D. B., Ye, J., Li, C. L., Wang, Y. H., Zhao, J., & Cai, S. Q. (2009). Antiaging effect of Cordyceps sinensis extract. Phytotherapy Research, 23(1), 116–122. https://doi.org/10.1002/ptr.2576

.
Skye is the founder of Real Mushrooms. Read more about his story into medicinal mushrooms here. When he’s not spreading the word of Real Mushrooms, he enjoys mushroom foraging, bouldering, cooking, gardening and hiking.

Disclaimer: The information or products mentioned in this article are provided as information resources only, and are not to be used or relied on to diagnose, treat, cure, or prevent any disease. This information does not create any patient-doctor relationship, and should not be used as a substitute for professional diagnosis and treatment. The information is intended for health care professionals only. The statements made in this article have not been evaluated by the Food and Drug Administration. Any products mentioned are not intended to diagnose, treat, cure, or prevent any disease. The information in this article is intended for educational purposes. The information is not intended to replace medical advice offered by licensed medical physicians. Please consult your doctor or health practitioner for any medical advice.

chevron-down